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Title   전이성 폐암환자에서 항암화학요법후 병소위치별 치료반응의 차이 ( The Site-dependent Differences in Response to Chemotherapy in Patients with Advanced Lung Cancer )
Publicationinfo   1999 Jan; 031(03): 533-539.
Key_word   Lung cancer, Response, Chemotherapy, Metastasis
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Abstract   Purpose: To detennine the extent and the clinical significance of site-dependent differ- ences in response to chemotherapy in patients with metastatic lung cancer. Materials: We reviewed the records of patients with metastatic lung cancer who had received chemotherapy and were evaluated for the response of primary lung and metastatic lesions simultaneously. Total 52 patients were eligible. Results: The discordance rate of response between primary lung lesion and various meta- static lesions was 0% (0/51) at regional lymph nodes, 12% (1/8) at distant lymph nodes, 45% (5/11) at hematogenous metastatic lung lesion, 0% (0/7) at liver, 50% at adrenal glands, and 21% (3/14) at bone. As a result, the concordance rate of response amang lymph nodes, liver, and primary lung lesions was high. But some differences in response were observed at intrapulmonary metastatic lesion, adrenal glands, and bone lesions in comparison with primary lung lesion. Conclusion: We conclude that the effective therapeutic strategies against those discordant metastatic lesions should be developed to increase the overall treatment effect in patients with metastatic lung cancer.
저 자   김기원(Kee Won Kim),이숙경(Sook Kyung Lee),서지원(Jee Won Seo),박석영(Suk Young Park),이경식(Kyung Shik Lee)